Substance P/calcitonin gene-related peptide and their receptors expression in human periodontal ligament after root canal preparation with five different systems.
Javier Caviedes BrucheliHernan Dario Muñoz-AlvearLuis Fernando Lopez-MoncayoKranthi Raja KacharajuAdriana Carolina Velasquez-RiveraLuis Alberto Carlosama-RecaldeJuan Camilo PazmiñoJose Francisco Gomez-SosaLuis-Eduardo DiazHugo Roberto MunozPublished in: International endodontic journal (2024)
Root canal preparation with hand files and Reciproc Blue generates the highest expression of SP, CGRP, NK1 and CGRP1R in human periodontal ligament, whilst Plex-V and HyFlex maintain the basal expression of neuropeptides and their receptors. Mtwo showed intermediate results between Reciproc Blue and HyFlex.