Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
Siyin WuTian JinBingjie MaYun JiXuehua HuangPeiliang WangXiaoming LiuBoris V KrylovXianguo LiuKe MaPublished in: Cancer medicine (2023)
L-TAMS outperforms a placebo in enhancing the analgesic effect of opioids and reducing the necessary opioid dosage. Moreover, L-TAMS can significantly relieve opioid-induced constipation. These advantages may be beneficial to patients with advanced cancer.
Keyphrases
- pain management
- double blind
- advanced cancer
- chronic pain
- palliative care
- placebo controlled
- clinical trial
- phase iii
- high glucose
- study protocol
- diabetic rats
- phase ii
- neuropathic pain
- irritable bowel syndrome
- randomized controlled trial
- drug induced
- anti inflammatory
- open label
- oxidative stress
- stress induced
- postoperative pain
- ultrasound guided