Design for a Multicentre Prospective Cohort for the Assessment of Platelet Function in Patients with Hepatitis-B-Virus-Related Acute-on-Chronic Liver Failure.
Xiuhua JiangShiqi ChaiYan HuangZuxiong HuangWenting TanYanhang GaoXiaobo LuZhong Ji MengHuayou ZhouWenbing KongXiaoting TangYujun TangTingting QiChengjin LiaoQiaorong GanXiaomei XiangYanan ZhangShuai WangYuanyuan ChenJinjun ChenPublished in: Clinical epidemiology (2022)
In this study, 586 participants were enrolled, including 100 in derivation cohort, 133 in internal validation cohort, and 353 in external validation cohort. Biomaterials, including plasma, serum, urine, and some explanted liver tissues, were collected from these patients. A 3-month follow-up with survival status was completed. The baseline characteristics indicated that 51% of the patients had adenosine diphosphate (ADP)-hyporesponsive circulating platelets. The prognostic potential of platelet function will be explored in the derivation cohort (HBV-related ACLF patients) and further substantiated in the validation cohorts (HBV-related and non-HBV-related ACLF patients). Biosamples are currently used to explore the underlying mechanisms related to ADP-hyporesponsive platelets. The ongoing proteomic and metabolic analyses will provide new insights into the pathogenesis of extrahepatic organ failures in ACLF patients.
Keyphrases
- hepatitis b virus
- liver failure
- end stage renal disease
- ejection fraction
- chronic kidney disease
- prognostic factors
- gene expression
- clinical trial
- patient reported outcomes
- randomized controlled trial
- climate change
- extracorporeal membrane oxygenation
- cross sectional
- mechanical ventilation
- drug induced
- acute respiratory distress syndrome
- respiratory failure