A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Nonsuicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine.
Bartholt Bloomfield-ClagettElizabeth D BallardDeanna K GreensteinSamuel T WilkinsonMichael F GrunebaumJames W MurroughSanjay J MathewJennifer L PhillipsMaurizio FavaGerard SanacoraCarlos A ZaratePublished in: The international journal of neuropsychopharmacology (2022)
Taken together, the results provide preliminary evidence of a differential placebo response for suicidal ideation vs other depressive symptoms, while anxiety and suicidal ideation appear to produce similar placebo response profiles. These findings may help explain the more modest findings in clinical IV ketamine trials for suicidal ideation than overall depression.