Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial.
Ekkehard GrünigAlison MacKenzieAndrew J PeacockChristina A EichstaedtNicola BenjaminRobert NechwatalStéphanie SaxerStéphanie SaxerMaurizio BussottiMarinella SommarugaStefano GhioLina GumbieneEglė PalevičiūtėElena JurevičienėAntonio CittadiniAnna A StanziolaAlberto Maria MarraGabor KovacsHorst OlschewskiJoan-Albert BarberàIsabel BlancoMartijn A. SpruitFrits M E FranssenAnton Vonk NoordegraafAbílio ReisMário SantosSofia Gonçalves ViamonteHeleen DemeyerMarion DelcroixEduardo BossoneMartin K JohnsonPublished in: European heart journal (2021)
This is the first multicentre and so far the largest randomized, controlled study on feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH. Within this study, a standardized specialized training programme with in-hospital start was successfully established in 10 European countries.
Keyphrases
- study protocol
- pulmonary hypertension
- randomized controlled trial
- double blind
- clinical trial
- open label
- placebo controlled
- healthcare
- skeletal muscle
- pulmonary artery
- phase iii
- pulmonary arterial hypertension
- palliative care
- cross sectional
- phase ii
- emergency department
- systematic review
- mesenchymal stem cells
- cell therapy
- acute care
- replacement therapy
- electronic health record
- polycyclic aromatic hydrocarbons