Differential brain region-specific expression of MeCP2 and BDNF in Rett Syndrome patients: a distinct grey-white matter variation.
S PejhanVictoria Mok SiuL C AngM R Del BigioMojgan RastegarPublished in: Neuropathology and applied neurobiology (2020)
Our findings indicate that MeCP2 protein is widely expressed in mature human brain cells at all ages. However, our data points towards a possible white matter abnormality in RTT and highlights the importance of studying human RTT brain tissues in parallel with research on animal and cell models of RTT.
Keyphrases
- white matter
- multiple sclerosis
- end stage renal disease
- endothelial cells
- newly diagnosed
- induced apoptosis
- poor prognosis
- ejection fraction
- chronic kidney disease
- gene expression
- peritoneal dialysis
- single cell
- binding protein
- prognostic factors
- cell cycle arrest
- resting state
- bone marrow
- case report
- induced pluripotent stem cells
- cell proliferation
- long non coding rna
- patient reported outcomes
- cell death
- pluripotent stem cells
- patient reported
- artificial intelligence
- subarachnoid hemorrhage