Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice.

Wen-Ting Hsiao Hui-Min Su Wen-Pang Su Szu-Han Chen Hai-Ping Wu Yi-Ling You Ru-Huei Fu Pei-Min Chao

Published in: Nutrition research and practice (2019)

LCPUFA enzyme expression was altered by PPARα. Either PPARα deficiency or activation-decreased tissue DHA concentration is a stimulus for further studies to determine the functional significance.

Keyphrases

fatty acid
insulin resistance
poor prognosis
replacement therapy
type diabetes
metabolic syndrome
adipose tissue
wild type
oxide nanoparticles