Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.

Rob HillJulie SanchezLaura LemelMirjana AntonijevicYselkla HoskingShailesh N MistryAndrew C KruegelJonathan A JavitchJ Robert Lane Meritxell Canals

Published in: British journal of pharmacology (2023)

Our data show that in addition to providing effective anti-nociception, the novel opioids, oliceridine, tianeptine, and SR-17018 depress respiration in male mice. However, the different potencies and kinetics of effect between these novel opioids may be relevant to their therapeutic application in different clinical settings.

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