J Robert Lane

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 27

Top Venues

Journal of medicinal chemistry

ACS chemical neuroscience

Science signaling

The Journal of biological chemistry

University of Nottingham

University of Glasgow School of Life Sciences (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Nottingham Sep 01 2019

United Kingdom

Associate Professor in Molecular Pharmacology :: Centre for Membrane Proteins and Receptors

University of Nottingham Oct 01 2018

United Kingdom

Assistant Professor in Molecular Pharmacology :: Centre of Receptors and Membrane Proteins (COMPARE), School of Life Sciences

Columbia University Medical Center Aug 01 2017 - Aug 14 2018

United States

Schaefer Research Scholar :: Psychiatry

Monash Institute of Pharmaceutical Sciences - Aug 01 2018

Australia

Larkin's Fellow/R.D. Wright Career Development Fellow :: Drug Discovery Biology

Universiteit Leiden

Netherlands

Post-Doctoral Researcher/ VENI Fellow :: Department of Medicinal Chemistry

Education History

University of Glasgow School of Life Sciences

United Kingdom

PHD :: Molecular Pharmacology

University of Bristol

United Kingdom

BSC :: Biochemistry

Publications

Meng-Hua M Tsai, Li Chen, Michael H Baumann, Meritxell Canals, Jonathan A Javitch, J Robert Lane, Lei Shi
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS chemical neuroscience 15 (4) (2024)
Meng-Hua M Tsai, Li Chen, Michael H Baumann, Meritxell Canals, Jonathan A Javitch, J Robert Lane, Lei Shi
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS chemical neuroscience (2024)
Meng-Hua M Tsai, Li Chen, Michael H Baumann, Meritxell Canals, Jonathan A Javitch, J Robert Lane, Lei Shi
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS chemical neuroscience 15 (4) (2024)
Meng-Hua M Tsai, Li Chen, Michael H Baumann, Meritxell Canals, Jonathan A Javitch, J Robert Lane, Lei Shi
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS chemical neuroscience 15 (4) (2024)
Meng-Hua M Tsai, Li Chen, Michael H Baumann, Meritxell Canals, Jonathan A Javitch, J Robert Lane, Lei Shi
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS chemical neuroscience 15 (4) (2024)
Rob Hill, Julie Sanchez, Laura Lemel, Mirjana Antonijevic, Yselkla Hosking, Shailesh N Mistry, Andrew C Kruegel, Jonathan A Javitch, J Robert Lane, Meritxell Canals
Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. British journal of pharmacology (2023)
Emma S Gogarnoiu, Caleb D Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik, Omar Soler-Cedeño, Guo-Hua Bi, Benjamin Klein, Zheng-Xiong Xi, J Robert Lane, Amy Hauck Newman
Dopamine D 3 /D 2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders. Journal of medicinal chemistry (2023)
Emma S Gogarnoiu, Caleb D Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik, Omar Soler-Cedeño, Guo-Hua Bi, Benjamin Klein, Zheng-Xiong Xi, J Robert Lane, Amy Hauck Newman
Dopamine D 3 /D 2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders. Journal of medicinal chemistry 66 (3) (2023)
Emma S Gogarnoiu, Caleb D Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik, Omar Soler-Cedeño, Guo-Hua Bi, Benjamin Klein, Zheng-Xiong Xi, J Robert Lane, Amy Hauck Newman
Dopamine D 3 /D 2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders. Journal of medicinal chemistry 66 (3) (2023)
Emma S Gogarnoiu, Caleb D Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik, Omar Soler-Cedeño, Guo-Hua Bi, Benjamin Klein, Zheng-Xiong Xi, J Robert Lane, Amy Hauck Newman
Dopamine D 3 /D 2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders. Journal of medicinal chemistry 66 (3) (2023)
Alessandro Bonifazi, Elizabeth Saab, Julie Sanchez, Antonina L Nazarova, Saheem A Zaidi, Khorshada Jahan, Vsevolod Katritch, Meritxell Canals, J Robert Lane, Amy Hauck Newman
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D 3 (D 3 R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. Journal of medicinal chemistry (2023)
R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan Jose Marugan, William C Wetsel, David R Sibley
Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity. ACS pharmacology & translational science 6 (1) (2022)
Alastair C Keen, Maria Hauge Pedersen, Laura Lemel, Daniel J Scott, Meritxell Canals, Dene R Littler, Travis Beddoe, Yuki Ono, Lei Shi, Asuka Inoue, Jonathan A Javitch, J Robert Lane
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα z . Communications biology 5 (1) (2022)
R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan Jose Marugan, William C Wetsel, David R Sibley
Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity. ACS pharmacology & translational science 6 (1) (2022)
Rob Hill, Andrew C Kruegel, Jonathan A Javitch, J Robert Lane, Meritxell Canals
The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine. British journal of pharmacology 179 (14) (2022)
Alessandro Bonifazi, Francisco O Battiti, Julie Sanchez, Saheem A Zaidi, Eric Bow, Mariia Makarova, Jianjing Cao, Anver Basha Shaik, Agnieszka Sulima, Kenner C Rice, Vsevolod Katritch, Meritxell Canals, J Robert Lane, Amy Hauck Newman
Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management. Journal of medicinal chemistry 64 (11) (2021)
Herman D Lim, J Robert Lane, Meritxell Canals, Richard J Payne
Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10. International journal of molecular sciences 22 (8) (2021)
Amy E Moritz, Alessandro Bonifazi, Adrian M Guerrero, Vivek Kumar, R Benjamin Free, J Robert Lane, Ravi Kumar Verma, Lei Shi, Amy Hauck Newman, David R Sibley
Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor. ACS chemical neuroscience 11 (20) (2020)
Alexander Gillis, Arisbel B Gondin, Andrea Kliewer, Julie Sanchez, Herman D Lim, Claudia Alamein, Preeti Manandhar, Marina J Santiago, Sebastian Fritzwanker, Frank Schmiedel, Timothy A Katte, Tristan A Reekie, Natasha L Grimsey, Michael Kassiou, Barrie Kellam, Cornelius Krasel, Michelle L Halls, Mark Connor, J Robert Lane, Stefan Schulz, Macdonald J Christie, Meritxell Canals
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Science signaling 13 (625) (2020)
Laura Lemel, J Robert Lane, Meritxell Canals
GRKs as Key Modulators of Opioid Receptor Function. Cells 9 (11) (2020)
Carmen Klein Herenbrink, Ravi Verma, Herman D Lim, Anitha Kopinathan, Alastair Keen, Jeremy Shonberg, Christopher J Draper-Joyce, Peter J Scammells, Arthur Christopoulos, Jonathan A Javitch, Ben Capuano, Lei Shi, J Robert Lane
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole. ACS chemical biology 14 (8) (2019)
Joseph M Schrader, Craig M Irving, J Christopher Octeau, Joseph A Christian, Timothy J Aballo, Dean J Kareemo, Joseph Conti, Jodi L Camberg, J Robert Lane, Jonathan A Javitch, Abraham Kovoor
The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface. The Journal of biological chemistry 294 (14) (2019)
Tim J Fyfe, Barrie Kellam, David A Sykes, Ben Capuano, Peter J Scammells, J Robert Lane, Steven J Charlton, Shailesh N Mistry
Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor. Journal of medicinal chemistry 62 (21) (2019)
Julie Sanchez, Zil E Huma, J Robert Lane, Xuyu Liu, Jessica L Bridgford, Richard J Payne, Meritxell Canals, Richard J Payne
Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1. The Journal of biological chemistry 294 (10) (2018)
Christopher J Draper-Joyce, Ravi Kumar Verma, Mayako Michino, Jeremy Shonberg, Anitha Kopinathan, Carmen Klein Herenbrink, Peter J Scammells, Ben Capuano, Ara M Abramyan, David M Thal, Jonathan A Javitch, Arthur Christopoulos, Lei Shi, J Robert Lane
The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions. Scientific reports 8 (1) (2018)
Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi
The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors. PLoS computational biology 14 (1) (2018)
Zil E Huma, Julie Sanchez, Herman D Lim, Jessica L Bridgford, Cheng Huang, Bradyn J Parker, Jiann G Pazhamalil, Benjamin T Porebski, Kevin D G Pfleger, J Robert Lane, Meritxell Canals, Richard J Payne
Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2. Science signaling 10 (480) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

J Robert Lane