Potential Implications of Quercetin and its Derivatives in Cardioprotection.
Kristina FerenczyovaBarbora KalocayovaMonika BartekovaPublished in: International journal of molecular sciences (2020)
Quercetin (QCT) is a natural polyphenolic compound enriched in human food, mainly in vegetables, fruits and berries. QCT and its main derivatives, such as rhamnetin, rutin, hyperoside, etc., have been documented to possess many beneficial effects in the human body including their positive effects in the cardiovascular system. However, clinical implications of QCT and its derivatives are still rare. In the current paper we provide a complex picture of the most recent knowledge on the effects of QCT and its derivatives in different types of cardiac injury, mainly in ischemia-reperfusion (I/R) injury of the heart, but also in other pathologies such as anthracycline-induced cardiotoxicity or oxidative stress-induced cardiac injury, documented in in vitro and ex vivo, as well as in in vivo experimental models of cardiac injury. Moreover, we focus on cardiac effects of QCT in presence of metabolic comorbidities in addition to cardiovascular disease (CVD). Finally, we provide a short summary of clinical studies focused on cardiac effects of QCT. In general, it seems that QCT and its metabolites exert strong cardioprotective effects in a wide range of experimental models of cardiac injury, likely via their antioxidant, anti-inflammatory and molecular pathways-modulating properties; however, ageing and presence of lifestyle-related comorbidities may confound their beneficial effects in heart disease. On the other hand, due to very limited number of clinical trials focused on cardiac effects of QCT and its derivatives, clinical data are inconclusive. Thus, additional well-designed human studies including a high enough number of patients testing different concentrations of QCT are needed to reveal real therapeutic potential of QCT in CVD. Finally, several negative or controversial effects of QCT in the heart have been reported, and this should be also taken into consideration in QCT-based approaches aimed to treat CVD in humans.
Keyphrases
- left ventricular
- endothelial cells
- cardiovascular disease
- clinical trial
- heart failure
- anti inflammatory
- end stage renal disease
- oxidative stress
- randomized controlled trial
- gene expression
- metabolic syndrome
- single cell
- signaling pathway
- atrial fibrillation
- pluripotent stem cells
- open label
- dna methylation
- machine learning
- human health
- chronic kidney disease
- pulmonary hypertension
- induced pluripotent stem cells
- drinking water
- peritoneal dialysis
- deep learning
- heavy metals
- weight loss
- cardiovascular events
- diabetic rats
- double blind
- patient reported