Lipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic Cancer.

Juho Pirhonen Ábel Szkalisity Jaana Hagstrom Yonghyo Kim Ede Migh Mária Kovács Maarit Hölttä Johan Peränen Hanna Seppänen Caj Haglund Jeovanis Gil Valdés Melinda Rezeli Johan Malm Peter Horvath Gyorgy Marko-Varga Pauli Puolakkainen Elina Ikonen

Published in: Cancer research (2022)

In clinically operable pancreatic cancer, regions distant from malignant cells already display proteomic changes related to lipid transport and metabolism that affect prognosis and may be pharmacologically targeted.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
fatty acid
induced pluripotent stem cells
cancer therapy
pluripotent stem cells
endoplasmic reticulum stress
cell death
oxidative stress
drug delivery