Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal.
Helen WhitelandAlessandra CruscoLisa W BloembergJamie Tibble-HowlingsJosephine E Forde-ThomasAvril CoghlanPatrick J MurphyKarl F HoffmannPublished in: PLoS neglected tropical diseases (2020)
To the best of our knowledge, this is the first demonstration that N-Acyl homoserines exhibit anthelmintic activities. Furthermore, their additional action on Gram+ bacteria opens a new avenue for exploring these molecules more broadly as part of future anti-infective initiatives.