Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia.
Barbara SpitzerKayleigh D RutherfordGunes GundemErin M McGovernNathan E MillardJuan E Arango OssaIrene Y CheungTeng GaoMax F LevineYanming ZhangJuan Santiago Medina-MartinezYi FengRyan N PtashkinKelly L BoltonNoushin FarnoudYangyu ZhouMinal A PatelGeorgios AsimomitisCassidy C CobbsNeeman MohibullahKety H HubermanMaria E ArcillaBrian H KushnerShakeel ModakAndrew L KungAhmet ZehirRoss L LevineScott A ArmstrongNai Kong V CheungElli PapaemmanuilPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
These findings demonstrate the clinical relevance of identifying molecular abnormalities in predicting development of t-MDS/AL and should guide the formation of intervention protocols to prevent this complication in high-risk pediatric patients.