TGF-β1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia.
Sabrina EhnertVrinda SreekumarRomina H Aspera-WerzSahar O SajadianElke WintermeyerGunther H SandmannChristian BahrsJan G HengstlerPatricio GodoyAndreas K NusslerPublished in: Journal of molecular medicine (Berlin, Germany) (2017)
Exposure to TGF-β1 induces expression of HDAC6 in human osteoblasts. TGF-β1 exposed human osteoblasts show less and distorted primary cilia. TGF-β1 exposed human osteoblasts are less sensitive towards mechanical stimulation. Mechanosensation can be recovered by HDAC6 inhibitor Tubacin in human osteoblasts.