Integrated Left Ventricular Global Transcriptome and Proteome Profiling in Human End-Stage Dilated Cardiomyopathy.
Dilek ColakAyodele A AlaiyaNamik KayaNzioka P MuiyaOlfat AlHaraziZakia ShinwariEditha AndresNduna DzimiriPublished in: PloS one (2016)
The concomitant use of transcriptome and proteome expression to evaluate global changes in DCM has led to the identification of sixteen commonly altered entities as well as novel genes, proteins and pathways whose cardiac functions have yet to be deciphered. This data should contribute towards better management of the disease.
Keyphrases
- left ventricular
- genome wide
- single cell
- rna seq
- bioinformatics analysis
- endothelial cells
- poor prognosis
- gene expression
- heart failure
- acute myocardial infarction
- dna methylation
- electronic health record
- aortic stenosis
- mitral valve
- cardiac resynchronization therapy
- induced pluripotent stem cells
- pluripotent stem cells
- left atrial
- binding protein
- big data
- long non coding rna
- genome wide identification
- ejection fraction