Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively.

Mauro Sola-PennaLarissa P PaixãoJessica R BrancoAlan C OchioniJamille M AlbaneseDavi M MundimDaniela Baptista-de-SouzaClaudia P FigueiredoWagner S CoelhoMariah C MarcondesPatricia Zancan

Published in: British journal of cancer (2019)

We showed that serotonin, through 5-HTR2A/C, interferes with breast cancer cells proliferation and metabolism by triggering two distinct signalling pathways: Jak1/STAT3 that boosts glycolysis through upregulation of PKM2, and adenylyl cyclase/PKA that enhances mitochondrial biogenesis.

Keyphrases

breast cancer cells
signaling pathway
endothelial cells
cell proliferation
pi k akt
oxidative stress
cell death
poor prognosis
induced pluripotent stem cells
pluripotent stem cells
long non coding rna