Blood transcriptomics analysis offers insights into variant-specific immune response to SARS-CoV-2.
Markus HoffmannLina-Liv WillruthAlexander DietrichHye Kyung LeeLudwig KnablNico TrummerJan BaumbachPriscilla A FurthLothar HennighausenMarkus ListPublished in: bioRxiv : the preprint server for biology (2023)
Computational deconvolution of transcriptomes can estimate immune cell abundances in SARS-CoV-2 patients, supplementing missing CBC data.10 million RNA sequencing reads per sample suffice for analyzing immune responses and disease severity, including BCR/TCR identification.
Keyphrases
- sars cov
- single cell
- immune response
- end stage renal disease
- respiratory syndrome coronavirus
- ejection fraction
- newly diagnosed
- chronic kidney disease
- acute lymphoblastic leukemia
- peritoneal dialysis
- regulatory t cells
- dendritic cells
- patient reported outcomes
- toll like receptor
- deep learning
- bioinformatics analysis