Muscle MRI as a biomarker of disease activity and progression in myotonic dystrophy type 1: a longitudinal study.
Laura FiondaLuca LeonardiLaura TufanoAntonio LaulettaStefania MorinoGioia MerlonghiRocco CostanzoElena RossiniFrancesca ForcinaDemetrio MarandoDavid Sarzi AmadèElisabetta BucciMarco SalvettiGiovanni AntoniniMatteo GaribaldiPublished in: Journal of neurology (2024)
Muscle MRI represents a sensitive biomarker of disease activity, severity, and progression in DM1. STIR alterations precede fat replacement and identify patients with a higher risk of disease progression, while T1-sequences reveal atrophy and fat replacement progression before clinical worsening.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- magnetic resonance imaging
- adipose tissue
- contrast enhanced
- skeletal muscle
- diffusion weighted imaging
- fatty acid
- early onset
- single cell
- computed tomography
- gene expression
- dna methylation