PRECIOUS study (PREterm Caesarean/vaginal birth and IVH/OUtcomeS): does mode of birth reduce the risk of death or brain injury in very preterm babies? A cohort and emulated target trial protocol.
David E OddNicola F ReeveJane BarnettJudith CutterRhian DanielChristopher GaleDimitris SiasakosPublished in: BMJ open (2024)
In this study, we will use deidentified data held in the National Neonatal Research Database (NNRD), an established national population database; parents can opt out of their baby's data being held in the NNRD. HRA/Health and Care Research Wales and National Health Service (NHS) study-specific Research Ethics Committee approval (London-Queen Square Research Ethics Committee) (Ref: 23/LO/0826) ethical approval has been obtained. Key outputs of the PRECIOUS (PREterm Caesarean/vaginal birth and IVH/OUutcomeS) study include the identification of the data, and accordingly of the multidisciplinary team required, to develop, gain funding and complete, a clinical trial to definitively identify the optimal mode of delivery for preterm infants and their mothers.
Keyphrases
- clinical trial
- brain injury
- preterm infants
- quality improvement
- healthcare
- gestational age
- public health
- low birth weight
- randomized controlled trial
- palliative care
- electronic health record
- machine learning
- study protocol
- metabolic syndrome
- weight loss
- open label
- health insurance
- pain management
- blood brain barrier
- decision making
- pregnancy outcomes
- glycemic control
- global health