Dose-Adjusted Etoposide, Doxorubicin, and Cyclophosphamide With Vincristine and Prednisone Plus Rituximab Therapy in Children and Adolescents With Primary Mediastinal B-Cell Lymphoma: A Multicenter Phase II Trial.
Gladstone A A BurkeVeronique Minard ColinAnne AupérinSarah AlexanderMarta PillonRafael DelgadoJózsef ZsírosAnne UyttebroeckPeggy DartiguesRodney R MilesBernarda KazanowskaAlan Kwok Shing ChiangStéphanie HaouyCatherine M BollardMonika CsokaKeith WheatleyDonald A BarkauskasPeter C AdamsonGilles VassalCatherine PatteThomas G GrossPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
DA-EPOCH-R did not improve the EFS compared with a historical control in this first prospective multisite international study of children and adolescents with PMLBL. Further studies are required to determine the optimum therapy for children and adolescents with this lymphoma.