Early Video Assisted Thoracoscopic Surgery (VATS) or Intrapleural Enzyme Therapy (IET) in Pleural Infection - A Feasibility Randomized Controlled Trial (The Third Multicenter Intrapleural Sepsis Trial - MIST-3).
Eihab O BedawiDionisios StavrouliasEmma HedleyKevin G BlythAlan KirkDuneesha De FonsekaJohn G EdwardsEveline InternulloJohn P CorcoranAdrian MarchbankRakesh PanchalEdward CaruanaOwais KadwaniLawrence OkirorTarek SabaManoj PurohitRachel M MercerRhona TaberhamNikolaos KanellakisAlison M CondliffeLeon G LewisDinesh N AddalaRachelle AsciakRadhika BankaVineeth GeorgeMaged HassanDavid McCrackenAnand SundaralingamJohn M WrightsonMelissa DobsonAlex WestGraham BarnesJohn HarveyMark SladeMae Chester-JonesSusan DuttonRobert F MillerNick A MaskellElizabeth BelcherNajib M RahmanPublished in: American journal of respiratory and critical care medicine (2023)
This is the first multicenter RCT of early IET vs early surgery in pleural infection. Despite logistical challenges posed by the COVID-19 pandemic, the study met its predefined feasibility criteria. Potential shortening of LOS with early surgery, and signals toward earlier resolution of pain and shortened recovery with IET were demonstrated. The study findings suggest that a definitive study is feasible and required to assess optimal initial management. Clinical trial registration available at www.isrctn.com, ID: ISRCTN18192121.
Keyphrases
- clinical trial
- randomized controlled trial
- minimally invasive
- study protocol
- coronary artery bypass
- chronic pain
- stem cells
- intensive care unit
- systematic review
- coronary artery disease
- neuropathic pain
- cross sectional
- climate change
- surgical site infection
- acute coronary syndrome
- open label
- phase iii
- tyrosine kinase
- thoracic surgery