A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine.

Fariba SaadatiSilvia CammaroneMarco A Ciufolini

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)

This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.

Keyphrases

coronavirus disease
sars cov
fatty acid
respiratory syndrome coronavirus
meta analyses
randomized controlled trial
systematic review
amino acid