SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops.

Anna Pacwa Joanna Machowicz Alicja Wojtyniak Marita Pietrucha-Dutczak Elisa Toropainen Ali K J Koskela Ewa Mrukwa-Kominek Joanna Lewin-Kowalik Adrian Smedowski

Published in: Journal of inflammation research (2022)

Inhibition of SCD1 in monocytes prevents their transformation into macrophages after exposure to saturated fatty acid derivatives contained in eye drops, which may contribute to the limitation of latent inflammation within ocular adnexa and could possibly translate into better tolerability of the topical treatment.

Keyphrases

fatty acid
oxidative stress
open label
dendritic cells
randomized controlled trial
peripheral blood
placebo controlled