Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia.
Giulia PonterioAnnalisa TassoneGiuseppe SciamannaValentina VanniMaria MeringoloMassimo SantoroNicola Biagio MercuriPaola BonsiAntonio PisaniPublished in: Movement disorders : official journal of the Movement Disorder Society (2017)
Mice with the DYT1 dystonia mutation exhibit an enhanced response to mu receptor activation, dependent on selective receptor gene upregulation. Our data suggest a novel role for striatal opioid signaling in motor control, and more important, identify mu opioid receptors as potential targets for pharmacological intervention in dystonia. © 2017 International Parkinson and Movement Disorder Society.
Keyphrases
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