Insulin Stimulates IL-23 Expression in Human Adipocytes: A Possible Explanation for the Higher Prevalence of Psoriasis in Obesity.
Roberto VettorMarnie GranzottoMarika CrescenziCamilla CostaStefano PiasericoVincenzo VindigniRoberto VettorMarco RossatoPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2023)
Here we show that human adipocytes spontaneously express IL-23 and that insulin stimulates IL-23 production by these cells in a specific manner as other stimuli, known to be involved in psoriasis pathophysiology, are ineffective. These observations could explain the association between psoriasis and obesity, a condition frequently characterized by a state of insulin hypersecretion.
Keyphrases
- type diabetes
- endothelial cells
- high fat diet induced
- insulin resistance
- metabolic syndrome
- glycemic control
- adipose tissue
- weight loss
- induced pluripotent stem cells
- poor prognosis
- induced apoptosis
- pluripotent stem cells
- weight gain
- risk factors
- cell proliferation
- long non coding rna
- body mass index
- physical activity
- binding protein