Potential Molecular Mechanisms of Alzheimer's Disease from Genetic Studies.
Martin NwadiugwuHui ShenHong-Wen DengPublished in: Biology (2023)
The devastating effects of Alzheimer's disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to identify common causes of molecular imbalance in AD and their potential mechanisms for continuing research. A narrative synthesis of molecular mechanisms in AD from primary studies that employed single-cell sequencing (scRNA-seq) or spatial genomics was conducted using Embase and PubMed databases. We found that differences in molecular mechanisms in AD could be grouped into four key categories: sex-specific features, early-onset features, aging, and immune system pathways. The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. What changed from previous findings in contrast to results obtained were explored to find potential factors for AD-modifying investigations.
Keyphrases
- single cell
- early onset
- rna seq
- cognitive decline
- induced apoptosis
- magnetic resonance
- genome wide
- late onset
- poor prognosis
- oxidative stress
- case control
- human health
- high throughput
- single molecule
- magnetic resonance imaging
- gene expression
- white matter
- blood brain barrier
- metabolic syndrome
- type diabetes
- long non coding rna
- deep learning
- big data
- brain injury
- insulin resistance
- contrast enhanced