Down-Regulated miR-21 in Gestational Diabetes Mellitus Placenta Induces PPAR-α to Inhibit Cell Proliferation and Infiltration.
Chun-Yi GuanShi TianJing-Li CaoXue-Qin WangXu MaHong-Fei XiaPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
The expression of the placental miR-21-5p, which inhibits cell growth and infiltration by up-regulating PPAR-α, is downregulated in pregnant GDM patients, which in turn may affect the placental function.
Keyphrases
- cell proliferation
- end stage renal disease
- pregnant women
- ejection fraction
- poor prognosis
- long non coding rna
- chronic kidney disease
- peritoneal dialysis
- transcription factor
- prognostic factors
- cell cycle
- fatty acid
- metabolic syndrome
- living cells
- adipose tissue
- patient reported outcomes
- fluorescent probe
- signaling pathway
- skeletal muscle