Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence.

Aldwin Suryo Rahmanto Fredrik J Swartling Olle Sangfelt

Published in: Molecular & cellular oncology (2016)

Cancer cells with stem-like properties are believed to contribute to treatment resistance, dissemination, and recurrence. SOX9 controls stem cell plasticity and its deregulation may provide a basis for tumor progression. Here, we summarize our findings of targeted SOX9 destruction by SCFFBW7 (Skp1/Cul1/F-box) in medulloblastoma and its potential for therapeutic intervention.

Keyphrases

stem cells
transcription factor
cancer therapy
randomized controlled trial
free survival
small cell lung cancer
squamous cell carcinoma
poor prognosis
cell therapy
combination therapy
long non coding rna
bone marrow