Bacterial endotoxin lipopolysaccharides regulate gene expression in human colon cancer cells.
Heping CaoPublished in: BMC research notes (2023)
LPS did not affect the viability of COLO 225 cells under the culture conditions but affected the expression of a number of genes important in inflammatory responses and cancer development. LPS increased TTP family, GLUT family and DGAT1 mRNA levels but decreased DGAT2a and DGAT2b expression in the human colon cancer cells. LPS also increased COX2, CXCL1, ELK1, ICAM1, TNFSF10 and ZFAND5 but decreased BCL2L1, CYP19A1 and E2F1 mRNA levels in the colon cancer cells. These data suggest that LPS has profound effects on gene expression in human colon cancer cells.
Keyphrases
- gene expression
- endothelial cells
- inflammatory response
- poor prognosis
- anti inflammatory
- induced pluripotent stem cells
- dna methylation
- binding protein
- pluripotent stem cells
- squamous cell carcinoma
- genome wide
- electronic health record
- cell cycle arrest
- young adults
- cell death
- intellectual disability
- cell proliferation
- big data
- squamous cell