Human Organic Anion Transporting Polypeptide 1B3 Applied as an MRI-Based Reporter Gene.
Song Ee BaekAsad Ul HaqDae Hee KimHyoung Wook ChoiMyeong Jin KimHye Jin ChoiHon Soul KimPublished in: Korean journal of radiology (2020)
The human endogenous OATP1B3 gene can be non-virally delivered into cells to induce transient OATP1B3 expression, leading to gadoxetic acid-mediated enhancement on MRI. These results indicate that hOATP1B3 can serve as an MRI-reporter gene while minimizing the risk of long-term complications.
Keyphrases
- contrast enhanced
- endothelial cells
- magnetic resonance imaging
- diffusion weighted imaging
- genome wide
- copy number
- genome wide identification
- crispr cas
- induced apoptosis
- induced pluripotent stem cells
- poor prognosis
- pluripotent stem cells
- cell cycle arrest
- magnetic resonance
- dna methylation
- cell death
- binding protein
- water soluble
- pi k akt