Omega-3 Polyunsaturated Fatty Acids Inhibit IL-17A Secretion through Decreased ICAM-1 Expression in T Cells Co-Cultured with Adipose-Derived Stem Cells Harvested from Adipose Tissues of Obese Subjects.

Marwa ChehimiRobert WardJulien PestelMaud RobertSandra PesentiNadia BendridiMarie-Caroline MichalskiMartine LavilleHubert VidalAssia Eljaafari

Published in: Molecular nutrition & food research (2019)

It is demonstrated herein that ALA inhibits Th17 cell promotion, through decreased ICAM-1expression in both ob-ASCs and monocytes. This novel mechanism may contribute to explain the beneficial effects of n-3 PUFA in IL-17A-related inflammatory pathologies.

Keyphrases

poor prognosis
adipose tissue
single cell
metabolic syndrome
gene expression
type diabetes
binding protein
insulin resistance
long non coding rna
weight loss
stem cells
bariatric surgery
mesenchymal stem cells
bone marrow