An exploratory double-blind, randomized, placebo-controlled study to assess the efficacy of CitruSlim on body composition and lipid parameters in obese individuals.
Juan L HanckeShalini SrivastavaDante Daniel Cáceres-LilloRafael Agustín BurgosPablo AlarconPublished in: Phytotherapy research : PTR (2021)
The prevalence of obesity in developing and developed countries has been well recognized, and the worldwide obesity rates have nearly tripled since 1975, according to the World Health Organization. CitruSlim, a standardized product containing a blend of Citrus bergamia and Eurycoma longifolia, can reduce cortisol, cholesterol, triglycerides, and hyperglycemia. These properties can contribute to reduction in body weight or body mass index (BMI) in obese patients. A randomized, double-blind, placebo-controlled clinical study was designed to evaluate the efficacy and tolerability of CitruSlim in body weight management in obese individuals, and the results were compared with that of placebo. A total of 97 participants were allocated, randomized, and treated with CitruSlim high-dose (HD, 400 mg), CitruSlim low-dose (LD, 200 mg), and placebo for 112 days. At the end of the study, CitruSlim HD and CitruSlim LD significantly reduced BMI compared to the placebo group and were well tolerated; however, it did not improve parameters associated with dyslipidemia and metabolic disturbances. The study findings suggested that CitruSlim was effective in reducing body weight in obese patients.
Keyphrases
- double blind
- body weight
- placebo controlled
- obese patients
- bariatric surgery
- weight loss
- body mass index
- phase iii
- clinical trial
- body composition
- low dose
- gastric bypass
- roux en y gastric bypass
- high dose
- phase ii
- weight gain
- metabolic syndrome
- type diabetes
- study protocol
- insulin resistance
- phase ii study
- adipose tissue
- risk factors
- resistance training
- oxidative stress
- fatty acid
- radiation therapy
- newly diagnosed
- randomized controlled trial
- stem cell transplantation