Association of Clinical Relapses With Disease Outcomes in Multiple Sclerosis Patients Older Than 50 Years.
Steffen PfeufferStephanie WolffDerya AslanLeoni RolfesMelanie KorsenMarc PawlitzkiPhilipp AlbrechtJoachim HavlaHagen B HuttnerChristoph KleinschnitzSven Guenther MeuthRefik PulTobias RuckPublished in: Neurology (2024)
A relapse-suggesting underlying active disease-in PwMS older than 50 years was associated with continued disease activity and increased risk of PIRA. Presence of CVRF and absence of DMT at baseline appeared as risk factors of disadvantageous disease courses. An escalation of DMT switch was associated with stable over active but not progressive disease.
Keyphrases
- multiple sclerosis
- disease activity
- risk factors
- rheumatoid arthritis
- systemic lupus erythematosus
- end stage renal disease
- ejection fraction
- randomized controlled trial
- type diabetes
- rheumatoid arthritis patients
- prognostic factors
- peritoneal dialysis
- community dwelling
- insulin resistance
- weight loss
- free survival