Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis.

Charlotte KlasenAnja MeyerPaula S WittekindIris WaquéSchafiq NabhaniDavid M Kofler

Published in: Arthritis research & therapy (2019)

EP4 is a potential marker of disease activity in patients with AS. Aberrant EP4 expression might contribute to pathogenic Th17 cell accumulation and represent a new target for the treatment of AS.

Keyphrases

disease activity
ankylosing spondylitis
rheumatoid arthritis
systemic lupus erythematosus
rheumatoid arthritis patients
poor prognosis
juvenile idiopathic arthritis
binding protein
induced apoptosis
single cell
stem cells
cell therapy
cell death
human health
climate change