Chemical Composition and in Vitro Cytotoxic Screening of Sixteen Commercial Essential Oils on Five Cancer Cell Lines.
Basma NajarJorge Eduardo ShortredeLuisa PistelliJoseph BuhagiarPublished in: Chemistry & biodiversity (2019)
The in vitro cytotoxic activity on human cancer cell lines of sixteen commercial EOs such as Aloysia citriodora, Boswellia sacra, Boswellia serrata, Cinnamomum zeylanicum, Cistus ladanifer, Citrus × aurantium, Citrus limon, Citrus sinensis, Cymbopogon citratus, Foeniculum vulgare, Illicium verum, Litsea cubeba, Satureja montana, Syzygium aromaticum, Thymus capitatus and Thymus vulgaris was performed using the MTT reduction assay. The screening was carried out on human cancer cells of breast adenocarcinoma (MCF7, T47D and MDA-MB-231), chronic myelogenous erythroleukemia (K562) and neuroblastoma cell lines (SH-SY5Y). C. zeylanicum and L. cubeba EOs were the most active on almost all the cell lines studied and thus could be promising as an anticancer agent. These two species showed a difference in their composition even though they belong to the Lauraceae family. Almost 57 % of the true cinnamon composition was made of (E)-cinnamaldehyde, while L. cubeba showed citral as the major compound (68.9 %). The K562 cells were the most sensitive to these oils with an IC50 ranging from 5.2 parts-per million (ppm) (C. zeylanicum) to 11.1 ppm (L. cubeba). The latter oil also showed an important cytotoxicity on MDA-MB-231 (13.4 ppm).
Keyphrases
- endothelial cells
- breast cancer cells
- papillary thyroid
- cell cycle arrest
- squamous cell
- induced pluripotent stem cells
- essential oil
- induced apoptosis
- pluripotent stem cells
- squamous cell carcinoma
- cell death
- high throughput
- radiation therapy
- pi k akt
- signaling pathway
- endoplasmic reticulum stress
- childhood cancer
- fatty acid
- cell proliferation
- genetic diversity
- single cell
- rectal cancer