ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress.

Sung-Yong YangMin Cheol PyoMi-Hyun NamKwang-Won Lee

Published in: BMC complementary and alternative medicine (2019)

Therefore, CA proved to be a stimulant of the expression of detoxification enzymes such as HO-1, GCLC, and GCLM through the ERK/Nrf2 pathway, and it may be an effective chemoprotective agent for protecting liver damage against oxidative damage.

Keyphrases

oxidative stress
pi k akt
signaling pathway
cell proliferation
poor prognosis
hydrogen peroxide
binding protein
long non coding rna