Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women.
Amnon BrzezinskiA SaadaH MillerN A Brzezinski-SinaiA Ben-MeirPublished in: Journal of ovarian research (2018)
This preliminary report indicates that molecular circadian clock genes exist in human luteinized granulosa cells. There is a decreased expression of some of these genes in older women. This decline may partially explain the decreased fertility and steroidogenesis of reproductive aging.
Keyphrases
- induced apoptosis
- endothelial cells
- poor prognosis
- genome wide
- cell cycle arrest
- bioinformatics analysis
- induced pluripotent stem cells
- genome wide identification
- pluripotent stem cells
- endoplasmic reticulum stress
- polycystic ovary syndrome
- cell death
- dna methylation
- gene expression
- adipose tissue
- long non coding rna
- single molecule