DNA Methylation at ABCG1 and Long-Term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial.
Xiang LiXiaojian ShaoMinghao KouXuan WangHao MaElin GrundbergLydia A BazzanoSteven R SmithGeorge A BrayFrank M SacksLu QiPublished in: Diabetes care (2023)
Baseline DNA methylation at ABCG1 interacted with dietary protein intake on long-term decreases in adiposity and body fat distribution. Participants with lower methylation at ABCG1 benefitted more in long-term reductions in body weight, waist circumference, and body fat distribution when consuming an average-protein diet.
Keyphrases
- body weight
- dna methylation
- genome wide
- body mass index
- gene expression
- physical activity
- insulin resistance
- weight gain
- protein protein
- adipose tissue
- clinical trial
- amino acid
- cancer stem cells
- study protocol
- weight loss
- copy number
- type diabetes
- randomized controlled trial
- small molecule
- phase ii
- binding protein
- fatty acid