Substance P enhances lactic acid and tyramine production in Enterococcus faecalis V583 and promotes its cytotoxic effect on intestinal Caco-2/TC7 cells.
Kelly BiagginiValérie BorrelSabine SzuneritsRabah BoukherroubAwa N'DiayeArthur ZébréMaryse Bonnin-JusserandGuillaume DuflosMarc FeuilloleyDjamel DriderPierre DéchelotteNathalie ConnilPublished in: Gut pathogens (2017)
SP can modulate the physiology of E. faecalis. Extensive studies are now needed to screen within the human microbiota which bacteria are responsive to host molecules, and to identify their sensors.