Simvastatin inhibits the expression of inflammatory cytokines and cell adhesion molecules induced by LPS in human dental pulp cells.

J Y JungS M WooW J KimB N LeeJ E NörKyung-San MinC H ChoiJ T KohK J LeeY C Hwang

Published in: International endodontic journal (2016)

Simvastatin has a suppressing effect on LPS-induced inflammatory cytokine, cell adhesion molecules and NF-κB transcription factors in HDPCs. Therefore, simvastatin might be a useful candidate as a pulp-capping agent in vital pulp therapy.

Keyphrases

cell adhesion
lps induced
inflammatory response
induced apoptosis
signaling pathway
transcription factor
endothelial cells
poor prognosis
oxidative stress
cell cycle arrest
toll like receptor
induced pluripotent stem cells
pluripotent stem cells
endoplasmic reticulum stress
dna binding