Hypomethylation and decreased expression of BRG1 in the myocardium of patients with congenital heart disease.
Yanyan QianDeyong XiaoXiao GuoHongbo ChenLili HaoXiaojing MaGuoying HuangDuan MaHuijun WangPublished in: Birth defects research (2017)
These results suggested that the early high expression of BRG1 in fetal hearts maintained normal cardiac development and that the abnormal hypomethylation and decreased expression of BRG1 in human hearts probably affect the expression of GATA4, which affects the pathogenesis of CHD. Birth Defects Research 109:1183-1195, 2017. © 2017 Wiley Periodicals, Inc.