Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial.
Mahdi MaghbouliSomayeh Alyan NajafAbadiGhazal MalekMahmoudiMohammad Hadi MolseghiPublished in: Brain and behavior (2023)
Considering that the addition of melatonin to routine anti-seizure treatment was effective in reducing the severity of epilepsy and improving sleep quality, it seems that melatonin can be useful as an adjunct therapy for EGTCS in well-defined circumstances.
Keyphrases
- double blind
- placebo controlled
- sleep quality
- temporal lobe epilepsy
- clinical trial
- phase ii
- phase iii
- cross sectional
- study protocol
- depressive symptoms
- phase ii study
- physical activity
- open label
- randomized controlled trial
- combination therapy
- squamous cell carcinoma
- type diabetes
- adipose tissue
- radiation therapy
- replacement therapy