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Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder - A Pilot Study.

Elizabeth RalevskiJenelle NewcombEmily PisaniDiana DeNegreMacKenzie R PeltierJane Serrita JaneGihyun YoonIsmene Petrakis
Published in: Journal of dual diagnosis (2024)
The findings from this study demonstrate that progesterone can be effective in reducing stress-induced craving, anxiety and negative affect in a laboratory setting in individuals with comorbid AUD and PTSD. Interestingly, progesterone also improved cognitive performance. These findings require replication in a larger clinical trial and may have implications for treatment among individuals with AUD and PTSD.This study was registered as NCT02187224, at www.clinicaltrials.gov.
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