Heart Involvement in Inflammatory Rheumatic Diseases: A Systematic Literature Review.
Florina Nicoleta BuleuElena SirbuAlexandru CarabaSimona DraganPublished in: Medicina (Kaunas, Lithuania) (2019)
Introduction: Patients with inflammatory rheumatic diseases have an increased risk of developing cardiovascular manifestations. The high risk of cardiovascular pathology in these patients is not only due to traditional cardiovascular risk factors (age, gender, family history, smoking, sedentary lifestyle, cholesterol), but also to chronic inflammation and autoimmunity. Aim: In this review, we present the mechanisms of cardiovascular comorbidities associated with inflammatory rheumatic diseases, as they have recently been reported by different authors, grouped in electrical abnormalities, valvular, myocardial and pericardial modifications and vascular involvement. Methods: We conducted a systematic search of published literature on the following online databases: EBSCO, ScienceDirect, Scopus and PubMed. Searches were limited to full-text English-language journal articles published between 2010 and 2017 using the following key words: heart, systemic inflammation, autoimmunity, rheumatic diseases and disease activity. After the primary analysis we included 50 scientific articles in this review. Results: The results showed that cardiac manifestations of systemic inflammation can occur frequently with different prevalence in rheumatoid arthritis (RA), systemic lupus erythematosus(SLE), systemic sclerosis(SSc) and ankylosing spondylitis(AS). Rheumatologic diseases can affect the myocardium, cardiac valves, pericardium, conduction system and arterial vasculature. Conclusions: Early detection, adequate management and therapy of specific cardiac involvement are essential in rheumatic disease. Electrocardiographic and echocardiographic evaluation should be performed as routine investigations in patients with inflammatory rheumatic diseases.
Keyphrases
- disease activity
- rheumatoid arthritis
- ankylosing spondylitis
- systemic lupus erythematosus
- left ventricular
- systemic sclerosis
- rheumatoid arthritis patients
- interstitial lung disease
- oxidative stress
- cardiovascular risk factors
- juvenile idiopathic arthritis
- physical activity
- heart failure
- end stage renal disease
- metabolic syndrome
- healthcare
- atrial fibrillation
- cardiovascular disease
- weight loss
- left atrial
- aortic valve
- chronic kidney disease
- systematic review
- randomized controlled trial
- newly diagnosed
- pulmonary hypertension
- autism spectrum disorder
- smoking cessation
- risk factors
- mental health
- health information
- aortic stenosis
- mitral valve
- patient reported outcomes
- bone marrow
- prognostic factors
- patient reported
- coronary artery disease
- machine learning