HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA.
Laurie R GrayRachel E JacksonPatrick E H JacksonStefan BekiranovDavid RekoshMarie-Louise HammarskjöldPublished in: Retrovirology (2019)
The HIV Rev protein can functionally interact with many RcREs present in the human genome, depending on the RcRE sequence, as well as the Rev sequence. This leads to export of some of the HERV-K proviral mRNAs and also has the potential to change the expression of non-viral genes.
Keyphrases
- endothelial cells
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- hiv testing
- genome wide
- hepatitis c virus
- binding protein
- induced pluripotent stem cells
- hiv aids
- pluripotent stem cells
- poor prognosis
- men who have sex with men
- sars cov
- amino acid
- dna methylation
- gene expression
- south africa
- transcription factor
- bioinformatics analysis