Impact of Bariatric Surgery on Adipose Tissue Biology.
Óscar Osorio-ConlesJosep VidalAna de HollandaPublished in: Journal of clinical medicine (2021)
Bariatric surgery (BS) procedures are actually the most effective intervention to help subjects with severe obesity achieve significant and sustained weight loss. White adipose tissue (WAT) is increasingly recognized as the largest endocrine organ. Unhealthy WAT expansion through adipocyte hypertrophy has pleiotropic effects on adipocyte function and promotes obesity-associated metabolic complications. WAT dysfunction in obesity encompasses an altered adipokine secretome, unresolved inflammation, dysregulated autophagy, inappropriate extracellular matrix remodeling and insufficient angiogenic potential. In the last 10 years, accumulating evidence suggests that BS can improve the WAT function beyond reducing the fat depot sizes. The causal relationships between improved WAT function and the health benefits of BS merits further investigation. This review summarizes the current knowledge on the short-, medium- and long-term outcomes of BS on the WAT composition and function.
Keyphrases
- weight loss
- adipose tissue
- bariatric surgery
- insulin resistance
- roux en y gastric bypass
- extracellular matrix
- metabolic syndrome
- high fat diet induced
- high fat diet
- oxidative stress
- type diabetes
- obese patients
- gastric bypass
- healthcare
- weight gain
- randomized controlled trial
- skeletal muscle
- cell death
- fatty acid
- glycemic control
- public health
- signaling pathway
- social media
- body mass index
- early onset
- health information
- climate change
- human health
- physical activity