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Clinical Trial Design Using A Stopped Negative Binomial Distribution.

Michelle DeVeauxMichael J KaneDaniel Zelterman
Published in: Statistics and its interface (2018)
We introduce a discrete distribution suggested by curtailed sampling rules common in early-stage clinical trials. We derive the distribution of the smallest number of independent and identically distributed Bernoulli trials needed to observe either s successes or t failures. This report provides a closed-form expression for the mass function, moment generating function, and provides connections to other, standard distributions.
Keyphrases
  • clinical trial
  • early stage
  • poor prognosis
  • phase ii
  • open label
  • study protocol
  • double blind
  • squamous cell carcinoma
  • randomized controlled trial
  • phase iii
  • sentinel lymph node
  • long non coding rna