Longitudinal Changes in Neuromelanin MRI Signal in Parkinson's Disease: A Progression Marker.

Rahul GauravLydia Yahia-CherifNadya PyatigorskayaGraziella MangoneEmma BiondettiRomain ValabrègueClaire EwenczykR Matthew HutchisonJesse M CedarbaumJean-Christophe CorvolMarie VidailhetStéphane Lehéricy

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

We observed a progressive and measurable decrease in neuromelanin-based SN signal and volume in PD, which might allow a direct noninvasive assessment of progression of SN loss and could represent a target biomarker for disease-modifying treatments. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

multiple sclerosis
magnetic resonance imaging
contrast enhanced
cross sectional
randomized controlled trial
magnetic resonance
systematic review
meta analyses