Canonical (CD74/CD44) and Non-Canonical (CXCR2, 4 and 7) MIF Receptors Are Differentially Expressed in Rheumatoid Arthritis Patients Evaluated by DAS28-ESR.
Gabriela Athziri Sánchez-ZunoRichard BucalaJorge Hernández-BelloIlce Valeria Román-FernándezMariel García-ChagollánFerdinando NicolettiMónica Guadalupe Matuz-FloresSamuel García-ArellanoJudith Alejandra Esparza-MichelSergio Cerpa-CruzPerez-Guerrero Edsaul EmilioJosé Francisco Munoz-VallePublished in: Journal of clinical medicine (2021)
The results support the need for further study of the role of sCD74 as a soluble MIF decoy receptor, sequestering it to negatively regulate MIF signaling though its membrane receptors. The expression patterns of CXCR4 and CXCR7 show that the latter is a scavenger-type receptor that prevents endocytosis and even degradation of CXCR4 under inflammatory conditions.