Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice.
Simon LebekXurde M CaraviaFrancesco ChemelloWei TanJohn R McAnallyKenian ChenLin XuNing LiuRhonda Bassel-DubyEric N OlsonPublished in: Circulation (2023)
Ablation of CaMKIIδ autophosphorylation by adenine base editing may offer a potential broad-based therapeutic concept for human cardiac disease.